Domenico Gagini was born in the Canton of Ticino, in Bissone, in the 1430s.
He began working as a sculptor in Genoa, where he built and decorated the chapel of San Giovanni Battista (St. John the Baptist) in Genoa Cathedral.
Later he moved to Southern Italy, first to Campania then to Sicily, importing his modern idea of art.
He settled in Palermo and brought about the Sicilian artistic dynasty of sculptors.