Ferdinando was born in Florence in 1699 to Antonio Fuga and Antonia Serravalli. He was first a pupil of Giovan Battista Foglini and then moved to Rome in 1718. In the capital, he had numerous assignments and was appointed Architect of the Sacred Palaces. His fame grew over time, so much so that he was called to Palermo and Naples. In Campania, he was an advocate of the building renovation promoted by the new King Charles of Bourbon. In the years 1753-54 he was elected prince of the Accademia di San Luca. He died in Naples in 1782.
From 1767 onwards, the architect, Fuga, made numerous changes and transformations to the cathedral, which, especially in the interior, also concealed parts of the previous building.