The altarpiece was created by Giandomenico Gagini for the 15th-century church of San Giorgio, and destroyed by the earthquake of 1693.
The limestone work is now set up inside a room adjacent to the left nave of the church.
The depiction follows the style of the period, influenced by the Spanish rule.
Originally, the polyptych was composed of several parts constituting a remarkable sculptural display that would have occupied the entire apse of the old church. Some ancient document report that the main chapel was decorated with 18 statues of saints made of a stone similar to marble.
