In 1474 the rector of the church, Giuliano Maniuni, ordered Antonello da Messina to create the Annunciation.
The painter, one of the most important artists in Italy, painted the requested work on a wooden panel, which remained above the altar until 1906.
That year, the Italian state offices responsible for managing Cultural Heritage purchased the painting; they ordered the work to be transferred to Syracuse for conservation and restoration.
Today Antonello da Messina’s Annunciation, restored and displayed on canvas, is preserved in the Bellomo Museum in Syracuse.